Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria.
Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria.
Auteurs : Shreeram Akilesh [États-Unis] ; Cynthia C. Nast [États-Unis] ; Michifumi Yamashita [États-Unis] ; Kammi Henriksen [États-Unis] ; Vivek Charu [États-Unis] ; Megan L. Troxell [États-Unis] ; Neeraja Kambham [États-Unis] ; Erika Bracamonte [États-Unis] ; Donald Houghton [États-Unis] ; Naila I. Ahmed [États-Unis] ; Chyi Chyi Chong [États-Unis] ; Bijin Thajudeen [États-Unis] ; Shehzad Rehman [États-Unis] ; Firas Khoury [États-Unis] ; Jonathan E. Zuckerman [États-Unis] ; Jeremy Gitomer [États-Unis] ; Parthassarathy C. Raguram [États-Unis] ; Shanza Mujeeb [États-Unis] ; Ulrike Schwarze [États-Unis] ; M Brendan Shannon [États-Unis] ; Iris De Castro [États-Unis] ; Charles E. Alpers [États-Unis] ; Behzad Najafian [États-Unis] ; Roberto F. Nicosia [États-Unis] ; Nicole K. Andeen [États-Unis] ; Kelly D. Smith [États-Unis]Source :
- American journal of kidney diseases : the official journal of the National Kidney Foundation [ 1523-6838 ] ; 2021.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Atteinte rénale aigüe (anatomopathologie), Atteinte rénale aigüe (étiologie), Diagnostic différentiel (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Protéinurie (anatomopathologie), Protéinurie (étiologie), Rein (anatomopathologie), Sujet âgé (MeSH), Études de suivi (MeSH).
- MESH :
- anatomopathologie : Atteinte rénale aigüe, Protéinurie, Rein.
- étiologie : Atteinte rénale aigüe, Protéinurie.
- Adulte, Adulte d'âge moyen, Diagnostic différentiel, Femelle, Humains, Mâle, Sujet âgé, Études de suivi.
English descriptors
- KwdEn :
- Acute Kidney Injury (etiology), Acute Kidney Injury (pathology), Adult (MeSH), Aged (MeSH), COVID-19 (complications), COVID-19 (pathology), Diagnosis, Differential (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Kidney (pathology), Male (MeSH), Middle Aged (MeSH), Proteinuria (etiology), Proteinuria (pathology).
- MESH :
- complications : COVID-19.
- etiology : Acute Kidney Injury, Proteinuria.
- pathology : Acute Kidney Injury, COVID-19, Kidney, Proteinuria.
- Adult, Aged, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged.
Abstract
RATIONALE & OBJECTIVE
Kidney biopsy data inform us about pathologic processes associated with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a multicenter evaluation of kidney biopsy findings in living patients to identify various kidney disease pathology findings in patients with coronavirus disease 2019 (COVID-19) and their association with SARS-CoV-2 infection.
STUDY DESIGN
Case series.
SETTING & PARTICIPANTS
We identified 14 native and 3 transplant kidney biopsies performed for cause in patients with documented recent or concurrent SARS-CoV-2 infection treated at 7 large hospital systems in the United States.
OBSERVATIONS
Men and women were equally represented in this case series, with a higher proportion of Black (n=8) and Hispanic (n=5) patients. All 17 patients had SARS-CoV-2 infection confirmed by reverse transcriptase-polymerase chain reaction, but only 3 presented with severe COVID-19 symptoms. Acute kidney injury (n=15) and proteinuria (n=11) were the most common indications for biopsy and these symptoms developed concurrently or within 1 week of COVID-19 symptoms in all patients. Acute tubular injury (n=14), collapsing glomerulopathy (n=7), and endothelial injury/thrombotic microangiopathy (n=6) were the most common histologic findings. 2 of the 3 transplant recipients developed active antibody-mediated rejection weeks after COVID-19. 8 patients required dialysis, but others improved with conservative management.
LIMITATIONS
Small study size and short clinical follow-up.
CONCLUSIONS
Cases of even symptomatically mild COVID-19 were accompanied by acute kidney injury and/or heavy proteinuria that prompted a diagnostic kidney biopsy. Although acute tubular injury was seen among most of them, uncommon pathology such as collapsing glomerulopathy and acute endothelial injury were detected, and most of these patients progressed to irreversible kidney injury and dialysis.
DOI: 10.1053/j.ajkd.2020.10.001
PubMed: 33045255
PubMed Central: PMC7546949
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Zuckerman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Gitomer, Jeremy" sort="Gitomer, Jeremy" uniqKey="Gitomer J" first="Jeremy" last="Gitomer">Jeremy Gitomer</name><affiliation wicri:level="2"><nlm:affiliation>Providence Alaska Medical Center, Anchorage, AK.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Providence Alaska Medical Center, Anchorage</wicri:cityArea></affiliation></author><author><name sortKey="Raguram, Parthassarathy C" sort="Raguram, Parthassarathy C" uniqKey="Raguram P" first="Parthassarathy C" last="Raguram">Parthassarathy C. 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Alpers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Najafian, Behzad" sort="Najafian, Behzad" uniqKey="Najafian B" first="Behzad" last="Najafian">Behzad Najafian</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Nicosia, Roberto F" sort="Nicosia, Roberto F" uniqKey="Nicosia R" first="Roberto F" last="Nicosia">Roberto F. Nicosia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Andeen, Nicole K" sort="Andeen, Nicole K" uniqKey="Andeen N" first="Nicole K" last="Andeen">Nicole K. Andeen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address: andeen@ohsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Pathology, Oregon Health & Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Kelly D" sort="Smith, Kelly D" uniqKey="Smith K" first="Kelly D" last="Smith">Kelly D. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA. Electronic address: kelsmith@uw.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33045255</idno><idno type="pmid">33045255</idno><idno type="doi">10.1053/j.ajkd.2020.10.001</idno><idno type="pmc">PMC7546949</idno><idno type="wicri:Area/Main/Corpus">000250</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000250</idno><idno type="wicri:Area/Main/Curation">000250</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000250</idno><idno type="wicri:Area/Main/Exploration">000250</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria.</title><author><name sortKey="Akilesh, Shreeram" sort="Akilesh, Shreeram" uniqKey="Akilesh S" first="Shreeram" last="Akilesh">Shreeram Akilesh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA. Electronic address: shreeram@uw.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Nast, Cynthia C" sort="Nast, Cynthia C" uniqKey="Nast C" first="Cynthia C" last="Nast">Cynthia C. Nast</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Yamashita, Michifumi" sort="Yamashita, Michifumi" uniqKey="Yamashita M" first="Michifumi" last="Yamashita">Michifumi Yamashita</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Henriksen, Kammi" sort="Henriksen, Kammi" uniqKey="Henriksen K" first="Kammi" last="Henriksen">Kammi Henriksen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Chicago, Chicago, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Pathology, University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Charu, Vivek" sort="Charu, Vivek" uniqKey="Charu V" first="Vivek" last="Charu">Vivek Charu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Troxell, Megan L" sort="Troxell, Megan L" uniqKey="Troxell M" first="Megan L" last="Troxell">Megan L. Troxell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Kambham, Neeraja" sort="Kambham, Neeraja" uniqKey="Kambham N" first="Neeraja" last="Kambham">Neeraja Kambham</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Bracamonte, Erika" sort="Bracamonte, Erika" uniqKey="Bracamonte E" first="Erika" last="Bracamonte">Erika Bracamonte</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Arizona, Tucson, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Department of Pathology, University of Arizona, Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Houghton, Donald" sort="Houghton, Donald" uniqKey="Houghton D" first="Donald" last="Houghton">Donald Houghton</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Oregon Health & Science University, Portland, OR.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Pathology, Oregon Health & Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Ahmed, Naila I" sort="Ahmed, Naila I" uniqKey="Ahmed N" first="Naila I" last="Ahmed">Naila I. Ahmed</name><affiliation wicri:level="2"><nlm:affiliation>Northeast Nephrology Consultants, Joliet, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northeast Nephrology Consultants, Joliet</wicri:cityArea></affiliation></author><author><name sortKey="Chong, Chyi Chyi" sort="Chong, Chyi Chyi" uniqKey="Chong C" first="Chyi Chyi" last="Chong">Chyi Chyi Chong</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, University of Arizona, Tucson, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, University of Arizona, Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Thajudeen, Bijin" sort="Thajudeen, Bijin" uniqKey="Thajudeen B" first="Bijin" last="Thajudeen">Bijin Thajudeen</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, University of Arizona, Tucson, AZ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, University of Arizona, Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Rehman, Shehzad" sort="Rehman, Shehzad" uniqKey="Rehman S" first="Shehzad" last="Rehman">Shehzad Rehman</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology Department of Medicine, Oregon Health & Science University, Portland, OR.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Division of Nephrology Department of Medicine, Oregon Health & Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Khoury, Firas" sort="Khoury, Firas" uniqKey="Khoury F" first="Firas" last="Khoury">Firas Khoury</name><affiliation wicri:level="2"><nlm:affiliation>Oregon Kidney & Hypertension Clinic, Portland, OR.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Oregon Kidney & Hypertension Clinic, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Zuckerman, Jonathan E" sort="Zuckerman, Jonathan E" uniqKey="Zuckerman J" first="Jonathan E" last="Zuckerman">Jonathan E. Zuckerman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Gitomer, Jeremy" sort="Gitomer, Jeremy" uniqKey="Gitomer J" first="Jeremy" last="Gitomer">Jeremy Gitomer</name><affiliation wicri:level="2"><nlm:affiliation>Providence Alaska Medical Center, Anchorage, AK.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alaska</region></placeName><wicri:cityArea>Providence Alaska Medical Center, Anchorage</wicri:cityArea></affiliation></author><author><name sortKey="Raguram, Parthassarathy C" sort="Raguram, Parthassarathy C" uniqKey="Raguram P" first="Parthassarathy C" last="Raguram">Parthassarathy C. Raguram</name><affiliation wicri:level="2"><nlm:affiliation>CHI Franciscan Nephrology Associates, Tacoma, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>CHI Franciscan Nephrology Associates, Tacoma</wicri:cityArea></affiliation></author><author><name sortKey="Mujeeb, Shanza" sort="Mujeeb, Shanza" uniqKey="Mujeeb S" first="Shanza" last="Mujeeb">Shanza Mujeeb</name><affiliation wicri:level="2"><nlm:affiliation>CHI Franciscan Nephrology Associates, Tacoma, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>CHI Franciscan Nephrology Associates, Tacoma</wicri:cityArea></affiliation></author><author><name sortKey="Schwarze, Ulrike" sort="Schwarze, Ulrike" uniqKey="Schwarze U" first="Ulrike" last="Schwarze">Ulrike Schwarze</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Shannon, M Brendan" sort="Shannon, M Brendan" uniqKey="Shannon M" first="M Brendan" last="Shannon">M Brendan Shannon</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="De Castro, Iris" sort="De Castro, Iris" uniqKey="De Castro I" first="Iris" last="De Castro">Iris De Castro</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Alpers, Charles E" sort="Alpers, Charles E" uniqKey="Alpers C" first="Charles E" last="Alpers">Charles E. Alpers</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Najafian, Behzad" sort="Najafian, Behzad" uniqKey="Najafian B" first="Behzad" last="Najafian">Behzad Najafian</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Nicosia, Roberto F" sort="Nicosia, Roberto F" uniqKey="Nicosia R" first="Roberto F" last="Nicosia">Roberto F. Nicosia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Andeen, Nicole K" sort="Andeen, Nicole K" uniqKey="Andeen N" first="Nicole K" last="Andeen">Nicole K. Andeen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address: andeen@ohsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Pathology, Oregon Health & Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Kelly D" sort="Smith, Kelly D" uniqKey="Smith K" first="Kelly D" last="Smith">Kelly D. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA. Electronic address: kelsmith@uw.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Washington, Seattle</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of kidney diseases : the official journal of the National Kidney Foundation</title><idno type="eISSN">1523-6838</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (etiology)</term><term>Acute Kidney Injury (pathology)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>COVID-19 (complications)</term><term>COVID-19 (pathology)</term><term>Diagnosis, Differential (MeSH)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Humans (MeSH)</term><term>Kidney (pathology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Proteinuria (etiology)</term><term>Proteinuria (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Atteinte rénale aigüe (anatomopathologie)</term><term>Atteinte rénale aigüe (étiologie)</term><term>Diagnostic différentiel (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Protéinurie (anatomopathologie)</term><term>Protéinurie (étiologie)</term><term>Rein (anatomopathologie)</term><term>Sujet âgé (MeSH)</term><term>Études de suivi (MeSH)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Atteinte rénale aigüe</term><term>Protéinurie</term><term>Rein</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Acute Kidney Injury</term><term>Proteinuria</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Kidney Injury</term><term>COVID-19</term><term>Kidney</term><term>Proteinuria</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Atteinte rénale aigüe</term><term>Protéinurie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>RATIONALE & OBJECTIVE</b></p><p>Kidney biopsy data inform us about pathologic processes associated with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a multicenter evaluation of kidney biopsy findings in living patients to identify various kidney disease pathology findings in patients with coronavirus disease 2019 (COVID-19) and their association with SARS-CoV-2 infection.</p></div><div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b></p><p>Case series.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING & PARTICIPANTS</b></p><p>We identified 14 native and 3 transplant kidney biopsies performed for cause in patients with documented recent or concurrent SARS-CoV-2 infection treated at 7 large hospital systems in the United States.</p></div><div type="abstract" xml:lang="en"><p><b>OBSERVATIONS</b></p><p>Men and women were equally represented in this case series, with a higher proportion of Black (n=8) and Hispanic (n=5) patients. All 17 patients had SARS-CoV-2 infection confirmed by reverse transcriptase-polymerase chain reaction, but only 3 presented with severe COVID-19 symptoms. Acute kidney injury (n=15) and proteinuria (n=11) were the most common indications for biopsy and these symptoms developed concurrently or within 1 week of COVID-19 symptoms in all patients. Acute tubular injury (n=14), collapsing glomerulopathy (n=7), and endothelial injury/thrombotic microangiopathy (n=6) were the most common histologic findings. 2 of the 3 transplant recipients developed active antibody-mediated rejection weeks after COVID-19. 8 patients required dialysis, but others improved with conservative management.</p></div><div type="abstract" xml:lang="en"><p><b>LIMITATIONS</b></p><p>Small study size and short clinical follow-up.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Cases of even symptomatically mild COVID-19 were accompanied by acute kidney injury and/or heavy proteinuria that prompted a diagnostic kidney biopsy. Although acute tubular injury was seen among most of them, uncommon pathology such as collapsing glomerulopathy and acute endothelial injury were detected, and most of these patients progressed to irreversible kidney injury and dialysis.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33045255</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>28</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-6838</ISSN><JournalIssue CitedMedium="Internet"><Volume>77</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>01</Month></PubDate></JournalIssue><Title>American journal of kidney diseases : the official journal of the National Kidney Foundation</Title><ISOAbbreviation>Am J Kidney Dis</ISOAbbreviation></Journal><ArticleTitle>Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria.</ArticleTitle><Pagination><MedlinePgn>82-93.e1</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0272-6386(20)31014-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1053/j.ajkd.2020.10.001</ELocationID><Abstract><AbstractText Label="RATIONALE & OBJECTIVE">Kidney biopsy data inform us about pathologic processes associated with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a multicenter evaluation of kidney biopsy findings in living patients to identify various kidney disease pathology findings in patients with coronavirus disease 2019 (COVID-19) and their association with SARS-CoV-2 infection.</AbstractText><AbstractText Label="STUDY DESIGN">Case series.</AbstractText><AbstractText Label="SETTING & PARTICIPANTS">We identified 14 native and 3 transplant kidney biopsies performed for cause in patients with documented recent or concurrent SARS-CoV-2 infection treated at 7 large hospital systems in the United States.</AbstractText><AbstractText Label="OBSERVATIONS">Men and women were equally represented in this case series, with a higher proportion of Black (n=8) and Hispanic (n=5) patients. All 17 patients had SARS-CoV-2 infection confirmed by reverse transcriptase-polymerase chain reaction, but only 3 presented with severe COVID-19 symptoms. Acute kidney injury (n=15) and proteinuria (n=11) were the most common indications for biopsy and these symptoms developed concurrently or within 1 week of COVID-19 symptoms in all patients. Acute tubular injury (n=14), collapsing glomerulopathy (n=7), and endothelial injury/thrombotic microangiopathy (n=6) were the most common histologic findings. 2 of the 3 transplant recipients developed active antibody-mediated rejection weeks after COVID-19. 8 patients required dialysis, but others improved with conservative management.</AbstractText><AbstractText Label="LIMITATIONS">Small study size and short clinical follow-up.</AbstractText><AbstractText Label="CONCLUSIONS">Cases of even symptomatically mild COVID-19 were accompanied by acute kidney injury and/or heavy proteinuria that prompted a diagnostic kidney biopsy. Although acute tubular injury was seen among most of them, uncommon pathology such as collapsing glomerulopathy and acute endothelial injury were detected, and most of these patients progressed to irreversible kidney injury and dialysis.</AbstractText><CopyrightInformation>Copyright © 2020 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Akilesh</LastName><ForeName>Shreeram</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA. Electronic address: shreeram@uw.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nast</LastName><ForeName>Cynthia C</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamashita</LastName><ForeName>Michifumi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henriksen</LastName><ForeName>Kammi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Chicago, Chicago, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Charu</LastName><ForeName>Vivek</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Troxell</LastName><ForeName>Megan L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kambham</LastName><ForeName>Neeraja</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bracamonte</LastName><ForeName>Erika</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Arizona, Tucson, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houghton</LastName><ForeName>Donald</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pathology, Oregon Health & Science University, Portland, OR.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Naila I</ForeName><Initials>NI</Initials><AffiliationInfo><Affiliation>Northeast Nephrology Consultants, Joliet, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chong</LastName><ForeName>Chyi Chyi</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, University of Arizona, Tucson, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thajudeen</LastName><ForeName>Bijin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, University of Arizona, Tucson, AZ.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rehman</LastName><ForeName>Shehzad</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Nephrology Department of Medicine, Oregon Health & Science University, Portland, OR.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khoury</LastName><ForeName>Firas</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Oregon Kidney & Hypertension Clinic, Portland, OR.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuckerman</LastName><ForeName>Jonathan E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gitomer</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Providence Alaska Medical Center, Anchorage, AK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raguram</LastName><ForeName>Parthassarathy C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>CHI Franciscan Nephrology Associates, Tacoma, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mujeeb</LastName><ForeName>Shanza</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CHI Franciscan Nephrology Associates, Tacoma, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwarze</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shannon</LastName><ForeName>M Brendan</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Castro</LastName><ForeName>Iris</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alpers</LastName><ForeName>Charles E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Najafian</LastName><ForeName>Behzad</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicosia</LastName><ForeName>Roberto F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andeen</LastName><ForeName>Nicole K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address: andeen@ohsu.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Kelly D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA. Electronic address: kelsmith@uw.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>KL2 TR001882</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Kidney Dis</MedlineTA><NlmUniqueID>8110075</NlmUniqueID><ISSNLinking>0272-6386</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011507" MajorTopicYN="N">Proteinuria</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Coronavirus disease 2019 (COVID-19)</Keyword><Keyword MajorTopicYN="Y">acute kidney injury (AKI)</Keyword><Keyword MajorTopicYN="Y">allograft biopsy</Keyword><Keyword MajorTopicYN="Y">antibody-mediated rejection (AMR)</Keyword><Keyword MajorTopicYN="Y">case series</Keyword><Keyword MajorTopicYN="Y">collapsing glomerulopathy</Keyword><Keyword MajorTopicYN="Y">kidney biopsy</Keyword><Keyword MajorTopicYN="Y">renal 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Smith</name><name sortKey="Thajudeen, Bijin" sort="Thajudeen, Bijin" uniqKey="Thajudeen B" first="Bijin" last="Thajudeen">Bijin Thajudeen</name><name sortKey="Troxell, Megan L" sort="Troxell, Megan L" uniqKey="Troxell M" first="Megan L" last="Troxell">Megan L. Troxell</name><name sortKey="Yamashita, Michifumi" sort="Yamashita, Michifumi" uniqKey="Yamashita M" first="Michifumi" last="Yamashita">Michifumi Yamashita</name><name sortKey="Zuckerman, Jonathan E" sort="Zuckerman, Jonathan E" uniqKey="Zuckerman J" first="Jonathan E" last="Zuckerman">Jonathan E. Zuckerman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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